対応OSはリリースノートにも記載されています。
| P4V | OS | |
| 2021.3 | Window (x86_64) | 7 8.1 10 |
| Mac OS X (x86_64) | 10.13 10.14 10.15 | |
| RHEL (x86_64) | 7.6 | |
| CentOS (x86_64) | 7.6 | |
| Ubuntu (x86_64) | 18.04 | |
| openSUSE (x86_64) | 15.1 | |
| 2021.2 | Windows (x86_64) ※32bitのサポート終了 | 7 8.1 10 |
| Mac OS X (x86_64) | 10.13 10.14 10.15 | |
| RHEL (x86_64) | 7.6 | |
| CentOS (x86_64) | 7.6 | |
| Ubuntu (x86_64) | 18.04 | |
| openSUSE (x86_64) | 15.1 | |
| 2021.1 | Windows (x86, x86_64) | 7 8.1 10 |
| Mac OS X (x86_64) | 10.13 10.14 10.15 | |
| RHEL (x86_64) | 7.6 | |
| CentOS (x86_64) | 7.6 | |
| Ubuntu (x86_64) | 18.04 | |
| openSUSE (x86_64) | 15.1 | |
| 2020.3 | Windows (x86, x86_64) | 7 8.1 10 |
| Mac OS X (x86_64) | 10.13 10.14 10.15 | |
| RHEL (x86_64) | 7.6 | |
| CentOS (x86_64) | 7.6 | |
| Ubuntu (x86_64) | 18.04 | |
| openSUSE (x86_64) | 15.1 | |
| 2020.2 | Windows (x86, x86_64) | 7 8.1 10 |
| Mac OS X (x86_64) | 10.13 10.14 10.15 | |
| RHEL (x86_64) | 7.4 | |
| CentOS (x86_64) | 7.4 | |
| Ubuntu (x86_64) | 18.04 | |
| openSUSE(x86_64) | 15.1 | |
| 2020.1 | Windows(x86, x86_64) | 7 8.1 10 |
| Mac OS X(x86_64) | 10.12 10.13 10.14 | |
| RHEL(x86_64) | 7.4 | |
| CentOS(x86_64) | 7.4 | |
| Ubuntu(x86_64) | 16.04 18.04 | |
| 2019.2 | Windows(x86, x86_64) | 7 8.1 10 |
| Mac OS X(x86_64) | 10.12 10.13 10.14 | |
| RHEL(x86_64) | 7.4 | |
| CentOS(x86_64) | 7.4 | |
| Ubuntu(x86_64) | 16.04 18.04 | |
| 2019.1 | Windows(x86, x86_64) | 7 8.1 10 |
| Mac OS X(x86_64) | 10.11 10.12 10.13 | |
| RHEL(x86_64) | 7.2 | |
| CentOS(x86_64) | 7.2 | |
| Ubuntu(x86_64) | 16.04 | |